Kennedy PJ, Allen AP, O'Neill A, Quigley EM, Cryan JF, Dinan TG, Clarke G

2015

April

Psychopharmacology

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Validated

()

232

8

1357

1371

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine can cross the blood brain barrier and lead to the production of neuroactive metabolites, which modulate glutamatergic and cholinergic signalling, key neurotransmitter systems involved in cognitive function.

10.1007/s00213-014-3767-z