O'Mahony AM, Desgranges S, Ogier J, Quinlan A, Devocelle M, Darcy R, Cryan JF, O'Driscoll CM

2013

April

Pharmaceutical research

In vitro investigations of the efficacy of cyclodextrin-siRNA complexes modified with lipid-PEG-Octaarginine: towards a formulation strategy for non-viral neuronal siRNA delivery.

Validated

Altmetric: 1 ()

30

4

1086

1098

Development of RNA interference based therapeutics for neurological and neurodegenerative diseases is hindered by a lack of non-viral vectors with suitable properties for systemic administration. Amphiphilic and cationic cyclodextrins (CD) offer potential for neuronal siRNA delivery. We aimed to improve our CD-based siRNA formulation through incorporation of a polyethyleneglycol (PEG) shielding layer and a cell penetrating peptide, octaarginine (R8).

10.1007/s11095-012-0945-8