Background Glycogen phosphorylase is a key enzyme in the regulation of glycogen
metabolism and consists of three isoenzymes, including glycogen phosphorylase
isoenzyme BB (GPBB). Pre-eclampsia, gestational hypertension, and small-for-gestational-
age (SGA) infants are complications in about 15% of all nulliparous pregnancies.
Biomarkers for these adverse pregnancy outcomes remain elusive. GPBB has been
proposed as a potential biomarker for the detection of these adverse outcomes.