Peer-Reviewed Journal Details
Mandatory Fields
Barry, N;Brondel, N;Lawrence, SE;Maguire, AR
2009
December
Tetrahedron
Synthesis of aryl benzyl NH-sulfoximines
Validated
WOS: 20 ()
Optional Fields
MUKAIYAMA ALDOL REACTIONS ONE-POT SYNTHESIS CATALYZED IMINATION UNSUBSTITUTED SULFOXIMINES SULFUR-COMPOUNDS SULFOXIDES SULFIDES PSEUDOPEPTIDES DERIVATIVES LIGANDS
65
10660
10670
Efficient synthesis and characterisation of a series of aryl benzyl NH-sulfoximines are described. While N-protected versions of aryl benzyl sulfoximines have been previously described, reports of their de-protection are very limited, presumably due to lability under the typically harsh deprotection conditions which can be employed with the less reactive aryl alkyl derivatives. Use of N-cyanosulfoximines as key intermediates overcomes these difficulties leading to an effective synthetic route to these compounds. (C) 2009 Elsevier Ltd. All rights reserved.
OXFORD
0040-4020
10.1016/j.tet.2009.10.056
Grant Details