Peer-Reviewed Journal Details
Mandatory Fields
MCDERMOTT, M;KASTNER, DL;HOLLOMAN, JD;SCHMIDTWOLF, G;LUNDBERG, AS;SINHA, AA;HSU, C;CASHIN, P;MOLLOY, MG;MULCAHY, B;OGARA, F;MCCONNELL, FI;ADAMS, C;KHAN, MA;WOLFE, F;RUBIN, LA;CLEGG, DO;HUSEBYE, D;AMOS, CI;WARD, RH;MCDEVITT, HO
1995
January
Arthritis and Rheumatism
THE ROLE OF T-CELL RECEPTOR-BETA CHAIN GENES IN SUSCEPTIBILITY TO RHEUMATOID-ARTHRITIS
Validated
WOS: 26 ()
Optional Fields
FRAGMENT-LENGTH-POLYMORPHISMS ASSOCIATION HAPLOTYPES
38
91
95
Objective. To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA). Methods. Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V(beta)6.7), a V(beta)12.2 SSCP marker, and a biallelic C-beta restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity-by-descent in affected sib-pairs. Results. Using the V(beta)12.2 marker, there was suggestive evidence of increased sib-pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V(beta)6.7 and C-beta yielded significance levels of 0.06 and 0.19, respectively. Conclusion. These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.
PHILADELPHIA
0004-3591
Grant Details