Gardiner, GE;Rea, MC;O'Riordan, B;O'Connor, P;Morgan, SM;Lawlor, PG;Lynch, PB;Cronin, M;Ross, RP;Hill, C

2007

November

Applied and Environmental Microbiology

Fate of the two-component lantibiotic lacticin 3147 in the gastrointestinal tract

Validated

WOS: 32 ()

ESCHERICHIA-COLI ANTIMICROBIAL ACTIVITY CAMPYLOBACTER-JEJUNI LACTOCOCCUS-LACTIS ENZYME-ACTIVITY BACTERIOCIN MORPHOLOGY MICROBIOTA MECHANISM PEPTIDES

73

7103

7109

The component peptides of lacticin 3147 were degraded by alpha-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.

WASHINGTON

0099-2240

10.1128/AEM.01117-07