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Mandatory Fields
Reviews
Denihan, NM;Boylan, GB;Murray, DM
2015
January
Metabolomic Profiling in Perinatal Asphyxia: A Promising New Field
Validated
1
WOS: 23 ()
Optional Fields
HYPOXIC-ISCHEMIC ENCEPHALOPATHY TERM NEONATAL ENCEPHALOPATHY BRAIN-INJURY CEREBROSPINAL-FLUID MILD HYPOTHERMIA ANIMAL-MODELS AMINO-ACIDS NEUROPROTECTION SEIZURES DAMAGE
Metabolomics, the latest "omic" technology, is defined as the comprehensive study of all low molecular weight biochemicals, "metabolites" present in an organism. As a systems biology approach, metabolomics has huge potential to progress our understanding of perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy, by uniquely detecting rapid biochemical pathway alterations in response to the hypoxic environment. The study of metabolomic biomarkers in the immediate neonatal period is not a trivial task and requires a number of specific considerations, unique to this disease and population. Recruiting a clearly defined cohort requires standardised multicentre recruitment with broad inclusion criteria and the participation of a range of multidisciplinary staff. Minimally invasive biospecimen collection is a priority for biomarker discovery. Umbilical cord blood presents an ideal medium as large volumes can be easily extracted and stored and the sample is not confounded by postnatal disease progression. Pristine biobanking and phenotyping are essential to ensure the validity of metabolomic findings. This paper provides an overview of the current state of the art in the field of metabolomics in perinatal asphyxia and neonatal hypoxic-ischaemic encephalopathy. We detail the considerations required to ensure high quality sampling and analysis, to support scientific progression in this important field.
NEW YORK
HINDAWI PUBLISHING CORPORATION
2314-6133
10.1155/2015/254076
Grant Details