Peer-Reviewed Journal Details
Mandatory Fields
Welsh, GI;Leney, SE;Lloyd-Lewis, B;Wherlock, M;Lindsay, AJ;McCaffrey, MW;Tavare, JM
2007
December
Journal of Cell Science
Rip11 is a Rab11-and AS160-RabGAP-binding protein required for insulin-stimulated glucose uptake in adipocytes
Validated
WOS: 31 ()
Optional Fields
GTPASE-ACTIVATING-PROTEIN RAB COUPLING PROTEIN 3T3-L1 ADIPOCYTES GLUT4 TRANSLOCATION PLASMA-MEMBRANE TRANSPORTER GLUT4 PHOSPHATIDYLINOSITOL 3-KINASE RAB11-INTERACTING PROTEINS GLUT4-CONTAINING VESICLES SUBCELLULAR-DISTRIBUTION
120
4197
4208
The translocation of GLUT4 to the plasma membrane underlies the ability of insulin to stimulate glucose uptake, an event that involves the activation of protein kinase B, several members of the Rab family of GTP-binding proteins and the phosphorylation of the Rab GTPase-activating protein AS160. Here, we explored the regulation by insulin of the class I Rab11-interacting proteins Rip11, RCP and FIP2. We show that Rip11, but not RCP or FIP2, translocates to the plasma membrane of 3T3-L1 adipocytes in response to insulin. This unique response of Rip11 prompted us to explore the role of this protein in more detail. We found that Rip11 partially colocalises with GLUT4 in intracellular compartments. siRNA-mediated knockdown of Rip11 inhibits insulin-stimulated uptake of 2-deoxyglucose, and overexpression of Rip11 blocks insulin-stimulated insertion of translocated GLUT4 vesicles into the plasma membrane. We additionally show that Rip11 forms a complex with AS160 in a Rab11-independent manner and that insulin induces dissociation of AS160 from Rip11. We propose that Rip11 is an AS160-and Rab-binding protein that coordinates the protein kinase signalling and trafficking machinery required to stimulate glucose uptake in response to insulin.
CAMBRIDGE
0021-9533
10.1242/jcs.007310
Grant Details