Peer-Reviewed Journal Details
Mandatory Fields
Galvin, M;Hill, C;Ross, RP
1999
May
Letters In Applied Microbiology
Lacticin 3147 displays activity in buffer against Gram-positive bacterial pathogens which appear insensitive in standard plate assays
Validated
WOS: 83 ()
Optional Fields
BROAD-SPECTRUM BACTERIOCIN LACTOCOCCUS-LACTIS
28
355
358
Lacticin 3147 is a broad-spectrum bacteriocin produced by Lactococcus lactis subsp. lactis DPC3147, which has been shown to be active against a range of food-borne bacteria. The reported inhibitory range for lacticin is extended to include methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis, penicillin-resistant Pneumococcus, Propionibacterium acne and Streptococcus mutans. This extended host range is not obvious from traditional agar plate-based methods, but reductions in bacterial cell numbers by up to 6 log(10) cfu ml(-1) was observed after 2 h in time-kill curve studies conducted in broth, suggesting that the bacteriocin may have potential as a therapeutic agent in the treatment of human infections.
OXFORD
0266-8254
Grant Details