Flynn, CJ;Elcoate, CJ;Lawrence, SE;Maguire, AR

2010

February

Journal of the American Chemical Society

Highly Enantioselective Intramolecular Copper Catalyzed C-H Insertion Reactions of alpha-Diazosulfones

Validated

WOS: 62 ()

RHODIUM CARBENOID INSERTIONS CARBON-HYDROGEN INSERTION BETA-KETO SULFONES PHENYLIODONIUM YLIDES ASYMMETRIC-SYNTHESIS BONDS CYCLOPROPANATION 2,2-DIOXIDES HETEROCYCLES SELECTIVITY

132

1184

Excellent enantiocontrol (up to 98% ee) is achieved in copper catalyzed C-H insertions of alpha-diazosulfones to form thiopyrans, with up to 60% ee in C-H insertions leading to sulfolanes.

WASHINGTON

0002-7863

10.1021/ja909713a