Peer-Reviewed Journal Details
Mandatory Fields
Mooij, MJ;O'Connor, HF;Tian, ZX;Wang, YP;Adams, C;Morrissey, JP;O'Gara, F
2010
June
Environmental microbiology reports
Antibiotic selection leads to inadvertent selection of nfxC-type phenotypic mutants in Pseudomonas aeruginosa
Validated
WOS: 4 ()
Optional Fields
REGULATOR RSMA PAO1 VIRULENCE REGULON SYSTEM MEXT
2
461
464
P>Spontaneous nfxC-type phenotypic mutants of Pseudomonas aeruginosa are characterized by chloramphenicol resistance and increased expression of the multidrug efflux pump, MexEF-OprN. These mutants frequently arise during the propagation of bacteria in laboratory conditions. This study shows that some of the discrepancies in transcriptomic/phenotypic profiles of two rsmA mutants, PAZH13 (rsmA mutant in strain PAO1) and PAK Delta rsmA, are due to the nfxC-type nature of PAZH13. This indicates that awareness of the possible occurrence of these spontaneous nfxC-type phenotypes is necessary. Screening of mexE levels could provide clarity when an nfxC-type phenotype is suspected.
MALDEN
1758-2229
10.1111/j.1758-2229.2010.00175.x
Grant Details