Peer-Reviewed Journal Details
Mandatory Fields
Ahern, RJ;Hanrahan, JP;Tobin, JM;Ryan, KB;Crean, AM
2013
November
European Journal of Pharmaceutical Sciences
Comparison of fenofibrate-mesoporous silica drug-loading processes for enhanced drug delivery
Validated
Optional Fields
SUPERCRITICAL CARBON-DIOXIDE AMORPHOUS STATE PHYSICAL STATE PORE-SIZE SBA-15 MCM-41 IBUPROFEN RELEASE DISSOLUTION FORMULATION
50
400
409
Loading a poorly water-soluble drug onto a high surface area carrier such as mesoporous silica (SBA-15) can increase the drug's dissolution rate and oral bioavailability. The loading method can influence subsequent drug properties including solid state structure and release rate. The objective of this research was to compare several loading processes in terms of drug distribution throughout the mesoporous silica matrix, drug solid state form and drug release properties. A model poorly water-soluble drug fenabrate was loaded onto SBA-15 using; (i) physical mixing, (ii) melt, (iii) solvent impregnation, (iv) liquid CO2 and (v) supercritical CO2 methods. Physical mixing resulted in heterogeneous drug-loading, with no evidence of drug in the mesopores and the retention of the drug in its crystalline state. The other loading processes yielded more homogeneous drug-loading; the drug was deposited into the mesopores of the SBA-15 and was non-crystalline. All the processing methods resulted in enhanced drug release compared to the unprocessed drug with the impregnation, liquid and SC-CO2 producing the greatest increase at t=30 min. (C) 2013 Elsevier B.V. All rights reserved.
AMSTERDAM
0928-0987
10.1016/j.ejps.2013.08.026
Grant Details