Peer-Reviewed Journal Details
Mandatory Fields
Nolan, MT;Bray, JTW;Eccles, K;Cheung, MS;Lin, ZY;Lawrence, SE;Whitwood, AC;Fairlamb, IJS;McGlacken, GP
2014
October
Tetrahedron
Pd-catalysed intramolecular regioselective arylation of 2-pyrones, pyridones, coumarins and quinolones by C-H bond functionalization
Validated
WOS: 26 ()
Optional Fields
METALATION-DEPROTONATION MECHANISM CHOLESTEROL ACYLTRANSFERASE CYCLIZATION REACTION OXIDATIVE ADDITION HECK REACTION ACYL-COA PALLADIUM 4-HYDROXY-2-PYRONES ACETYLCHOLINESTERASE IODOBENZENE
70
7120
7127
The intramolecular arylation of 2-pyrones, 2-pyridones, coumarins and quinolones is reported using Pd-II precatalyst sources without added phosphine ligands. The excellent yields and convenient reagents enables the formation of various analogues containing these moieties, and access to potential biologically active candidates. Stoichiometric studies were carried out to provide an insight into the oxidation addition step. A switch in regioselectivity, together with a hydrodebromination process, was observed in the case of a 3-bromo-2-pyrone. (C) 2014 Elsevier Ltd. All rights reserved.
OXFORD
0040-4020
10.1016/j.tet.2014.04.029
Grant Details