Peer-Reviewed Journal Details
Mandatory Fields
Eccles, KS;Deasy, RE;Fabian, L;Maguire, AR;Lawrence, SE
2011
February
The Journal of Organic Chemistry
The Use of Co-crystals for the Determination of Absolute Stereochemistry: An Alternative to Salt Formation
Validated
WOS: 15 ()
Optional Fields
COCRYSTALS ACIDS CONFIGURATION ISONICOTINAMIDE CRYSTALLOGRAPHY SOLIDS DESIGN DRUG
76
1159
1162
Absolute stereochemistry of oils and viscous liquids can be difficult to determine. Co-crystallization involves generating a crystalline material consisting of more than one neutral compound. The combination of co-crystallization with both X-ray diffraction and chiral HPLC was particularly powerful in overcoming these difficulties for a series of chiral 3-arylbutanoic acids. Co-crystallization offers advantages over salt formation because co-crystals dissociate in solution, meaning identical HPLC conditions can be used for both the materials of interest and their co-crystals.
WASHINGTON
0022-3263
10.1021/jo102148p
Grant Details