Deasy, RE;Brossat, M;Moody, TS;Maguire, AR

2011

January

Tetrahedron: Asymmetry

Lipase catalysed kinetic resolutions of 3-aryl alkanoic acids

Validated

Altmetric: 2 ()

CANDIDA-RUGOSA LIPASE ASYMMETRIC CONJUGATE REDUCTION OPTICALLY PURE ISOMERS UNUSUAL AMINO-ACIDS ALPHA,BETA-UNSATURATED KETONES ENANTIOSELECTIVE SYNTHESIS IMMOBILIZED LIPASE ORGANIC-SOLVENTS CARBOXYLIC-ACIDS ENZYMES

22

47

61

Hydrolase catalysed kinetic resolutions leading to a series of 3-aryl alkanoic acids (>= 94% ee) are described. Hydrolysis of the ethyl esters with a series of hydrolases was undertaken to identify biocatalysts that yield the corresponding acids with excellent enantiopurity in each case. Steric and electronic effects on the efficiency and enantioselectivity of the biocatalytic transformation were also explored. (C) 2011 Elsevier Ltd. All rights reserved.

OXFORD

0957-4166

10.1016/j.tetasy.2010.12.019