Viegelmann, C;Parker, J;Ooi, T;Clements, C;Abbott, G;Young, L;Kennedy, J;Dobson, ADW;Edrada-Ebel, R

2014

May

Marine Drugs

Isolation and Identification of Antitrypanosomal and Antimycobacterial Active Steroids from the Sponge Haliclona simulans

Validated

Altmetric: 2 ()

MARINE NATURAL-PRODUCTS STARFISH ACANTHASTER-PLANCI 2 GENUINE SAPOGENOLS MYCOBACTERIUM-TUBERCULOSIS TRYPANOSOMA-BRUCEI ORGANIC-CHEMISTRY ASTERIAS-FORBESI THORNASTEROL-B SIDE-CHAINS BIOSYNTHESIS

12

2937

2952

The marine sponge Haliclona simulans collected from the Irish Sea yielded two new steroids: 24-vinyl-cholest-9-ene-3 beta,24-diol and 20-methyl-pregn-6-en-3 beta-ol, 5 alpha,8 alpha-epidioxy, along with the widely distributed 24-methylenecholesterol. One of the steroids possesses an unusually short hydrocarbon side chain. The structures were elucidated using nuclear magnetic resonance spectroscopy and confirmed using electron impact-and high resolution electrospray-mass spectrometry. All three steroids possess antitrypanosomal and anti-mycobacterial activity. All the steroids were found to possess low cytotoxicity against Hs27 which was above their detected antitrypanosomal potent concentrations.

BASEL

1660-3397

10.3390/md12052937