Other Publication Details
Mandatory Fields
Reviews
Baranov, PV;Atkins, JF;Yordanova, MM
2015
September
Augmented genetic decoding: global, local and temporal alterations of decoding processes and codon meaning
Validated
1
WOS: 40 ()
Optional Fields
RIBOSOMAL FRAMESHIFT SIGNALS ORNITHINE-DECARBOXYLASE ANTIZYME MAMMALIAN THIOREDOXIN REDUCTASE OPEN READING FRAMES RNA G-QUADRUPLEX MESSENGER-RNA STOP-CODON SACCHAROMYCES-CEREVISIAE ESCHERICHIA-COLI UGA CODONS
The non-universality of the genetic code is now widely appreciated. Codes differ between organisms, and certain genes are known to alter the decoding rules in a site-specific manner. Recently discovered examples of decoding plasticity are particularly spectacular. These examples include organisms and organelles with disruptions of triplet continuity during the translation of many genes, viruses that alter the entire genetic code of their hosts and organisms that adjust their genetic code in response to changing environments. In this Review, we outline various modes of alternative genetic decoding and expand existing terminology to accommodate recently discovered manifestations of this seemingly sophisticated phenomenon.
LONDON
NATURE PUBLISHING GROUP
1471-0056
517
529
10.1038/nrg3963
Grant Details