1,3-AMINO ALCOHOL DERIVATIVES
TERT-BUTANESULFINYL IMINES
ACYCLIC AMINO-ALCOHOLS
MANNICH-TYPE REACTION
STEREOSELECTIVE-SYNTHESIS
BETA-AMINO
ENANTIOSELECTIVE SYNTHESIS
ANTI-1,3-AMINO ALCOHOLS
ORGANIC-SYNTHESIS
ALDEHYDES
Methods for the preparation of 1,3-amino alcohols and their derivatives containing two stereogenic centers usually involve a two-step installation of the chiral centers. An aldol-Tishchenko reaction of chiral sulfinimines which involves the first reported reduction of a C-N in this type of reaction is described. Two and even three chiral centers can be installed in one synthetic step, affording anti-1,3-amino alcohols in good diastereo- and enantioselectivity.