Peer-Reviewed Journal Details
Mandatory Fields
Foley, VM;McSweeney, CM;Eccles, KS;Lawrence, SE;McGlacken, GP
2015
November
Organic letters
Asymmetric Aldol-Tishchenko Reaction of Sulfinimines
Validated
Optional Fields
1,3-AMINO ALCOHOL DERIVATIVES TERT-BUTANESULFINYL IMINES ACYCLIC AMINO-ALCOHOLS MANNICH-TYPE REACTION STEREOSELECTIVE-SYNTHESIS BETA-AMINO ENANTIOSELECTIVE SYNTHESIS ANTI-1,3-AMINO ALCOHOLS ORGANIC-SYNTHESIS ALDEHYDES
17
5642
5645
Methods for the preparation of 1,3-amino alcohols and their derivatives containing two stereogenic centers usually involve a two-step installation of the chiral centers. An aldol-Tishchenko reaction of chiral sulfinimines which involves the first reported reduction of a C-N in this type of reaction is described. Two and even three chiral centers can be installed in one synthetic step, affording anti-1,3-amino alcohols in good diastereo- and enantioselectivity.
WASHINGTON
1523-7060
10.1021/acs.orglett.5b02919
Grant Details