Peer-Reviewed Journal Details
Mandatory Fields
Clarke, SL,McGlacken, GP
2015
May
Tetrahedron
Access to trifluoromethylated 4-alkoxy-2-pyrones, pyridones and quinolones
Validated
WOS: 21 ()
Optional Fields
Trifluoromethylation Pyrone Pyridone Quinolone Methyl fluorosulfonyldifluoroacetate Heteroaromatic MEDICINAL CHEMISTRY 2-PYRONES PYRONES FLUORINE FUNCTIONALIZATION HETEROCYCLES DERIVATIVES ANNULATION COUMARINS CATALYSIS
71
2906
2913
2-Pyrones, pyridones and quinolones represent classes of molecules with remarkable and diverse biological activity. The introduction of a trifluoromethyl group to a molecule can have dramatic and beneficial effects in terms of lipophilicity and bioavailability. Herein we report a route to afford a library of novel trifluoromethylated 2-pyrones, 2-pyridones and a 2-quinolone in moderate to good yield using methyl fluorosulfonyldifluoroacetate as the trifluoromethylating agent. (C) 2015 Published by Elsevier Ltd.
10.1016/j.tet.2015.03.061
Grant Details