Gobbo, OL,Wetterling, F,Vaes, P,Teughels, S,Markos, F,Edge, D,Shortt, CM,Crosbie-Staunton, K,Radomski, MW,Volkov, Y,Prina-Mello, A

2015

October

Nanomedicine

Biodistribution and pharmacokinetic studies of SPION using particle electron paramagnetic resonance, MRI and ICP-MS

Validated

WOS: 23 ()

biodistribution ICP-MS MRI nanomedicine pEPR pharmacokinetics SPION MAGNETIC NANOPARTICLES OXIDE NANOPARTICLES CONTRAST AGENT DRUG-DELIVERY NANOMEDICINE MANGANESE THERAPY RATS

10

1751

1760

Aim: Superparamagnetic iron oxide nanoparticles (SPIONs) may play an important role in nanomedicine by serving as drug carriers and imaging agents. In this study, we present the biodistribution and pharmacokinetic properties of SPIONs using a new detection method, particle electron paramagnetic resonance (pEPR). Materials & methods: The pEPR technique is based on a low-field and low-frequency electron paramagnetic resonance. pEPR was compared with inductively coupled plasma mass spectrometry and MRI, in in vitro and in vivo. Results: The pEPR, inductively coupled plasma mass spectrometry and MRI results showed a good correlation between the techniques. Conclusion: The results indicate that pEPR can be used to detect SPIONs in both preclinical and clinical studies.

10.2217/nnm.15.22