Peer-Reviewed Journal Details
Mandatory Fields
Healy, B,O'Mahony, J,Hill, C,Cotter, PD,Ross, RP,Wang, G
2010
October
Antimicrobial Peptides: Discovery, Design And Novel Therapeutic Strategies
Lantibiotic-related Research and the Application Thereof
Validated
()
Optional Fields
RESISTANT STAPHYLOCOCCUS-AUREUS GRAM-POSITIVE BACTERIA PRECURSOR LIPID-II SITE-DIRECTED MUTAGENESIS LACTIS SUBSP LACTIS LACTOCOCCUS-LACTIS GENE-CLUSTER STREPTOCOCCUS-MUTANS CHEDDAR CHEESE LACTOCIN-S
22
39
Since the 1925 discovery that strains of Escherichia coli can retard the growth of neighbouring bacteria, the study of bacteriocins has continuously evolved. During the intervening period, a large and heterogeneous collection of these antimicrobial peptides has been isolated from a myriad of sources and numerous investigations have been carried out with a view to harnessing their potency. The most thoroughly investigated class of bacteriocins, the lantibiotics, is the main focus of this review. These antimicrobial peptides inhibit many human and animal pathogens. They have been the focus of considerable efforts to maximize the potential of existing lantibiotics, identify new and better lantibiotics from nature and utilize bioengineering-based approaches to further improve upon existing well-characterized compounds.
Grant Details