Peer-Reviewed Journal Details
Mandatory Fields
Dennehy, O.C.; Cacheux, V.M.Y.; Deadman, B.J.; Lynch, D.; Collins, S.G.; Moynihan, H.A.; Maguire, A.R.
2016
November
Beilstein Journal Of Organic Chemistry
Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation
Validated
WOS: 5 ()
Optional Fields
α-thio-β-chloroacrylamides Cascade reactions Flow chemistry
12
2511
2522
A continuous process strategy has been developed for the preparation of α-thio-β chloroacrylamides, a class of highly versatile synthetic intermediates. Flow platforms to generate the α-chloroamide and α-thioamide precursors were successfully adopted, progressing from the previously employed batch chemistry, and in both instances afford a readily scalable methodology. The implementation of the key α-thio-β-chloroacrylamide casade as a continuous flow reaction on a multi-gram scale is described, while the tuneable nature of the cascade, facilitated by continuous processing, is highlighted by selective generation of established intermediates and byproducts.
1860-5397
10.3762/bjoc.12.246
Grant Details