Peer-Reviewed Journal Details
Mandatory Fields
Niu, Z.,Conejos-Sanchez, I.,Griffin, B. T.,O'Driscoll, C. M.,Alonso, M. J.
2016
November
Adv Drug Deliv Rev
Lipid-based nanocarriers for oral peptide delivery
Validated
Optional Fields
Lipid formulation Liposome Nano/microemulsion Nanocapsule Oral delivery Peptide drug Self-emulsifying system Solid lipid nanoparticle
106
Pt B
337
354
This article is aimed to overview the lipid-based nanostructures designed so far for the oral administration of peptides and proteins, and to analyze the influence of their composition and physicochemical (particle size, zeta potential) and pharmaceutical (drug loading and release) properties, on their interaction with the gastro-intestinal environment, and the subsequent PK/PD profile of the associated drugs. The ultimate goal has been to highlight and comparatively analyze the key factors that may be determinant of the success of these nanocarriers for oral peptide delivery. The article ends with some prospects on the challenges to be addressed for the intended commercial success of these delivery vehicles.
1872-8294 (Electronic) 01
https://www.ncbi.nlm.nih.gov/pubmed/27080735
10.1016/j.addr.2016.04.001
Grant Details