Peer-Reviewed Journal Details
Mandatory Fields
Shiely, Amy E.; Slattery, Catherine N.; Ford, Alan; Eccles, Kevin S.; Lawrence, Simon E.; Maguire, Anita R.
2017
February
Organic and Biomolecular Chemistry
Enantioselective copper catalysed intramolecular C-​H insertion reactions of α-​diazo-​β-​keto sulfones, α-​diazo-​β-​keto phosphine oxides and 2-​diazo-​1,​3-​diketones; the influence of the carbene substituent
Published
()
Optional Fields
15
2609
2628
Enantioselectivities in C–H insertion reactions, employing the copper-bis(oxazoline)-NaBARF catalyst system, leading to cyclopentanones are highest with sulfonyl substituents on the carbene carbon, and furthermore, the impact is enhanced by increased steric demand on the sulfonyl substituent (up to 91% ee). Enantioselective intramolecular C–H insertion reactions of α-diazo-β-keto phosphine oxides and 2-diazo-1,3-diketones are reported for the first time.
1477-0520
10.1039/C7OB00214A
Grant Details