McKernan, DP; Fitzgerald, P; Dinan, TG; Cryan, JF;

2010

June

Neurogastroenterology and Motility

The probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat.

Validated

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Irritable bowel syndrome (IBS) is characterized by recurrent abdominal pain and altering bowel habit with a high percentage of patients displaying comorbid anxiety. Growing clinical and preclinical evidence suggests that probiotic agents may restore the altered brain-gut communication in IBS. In this study, we evaluated the efficacy of repeated treatment with three different probiotics in reducing visceral pain in visceral normosensitive (Sprague-Dawley [SD]) and visceral hypersensitive (Wistar-Kyoto [WKY]) rat strains.

10.1111/j.1365-2982.2010.01520.x