Peer-Reviewed Journal Details
Mandatory Fields
McCaw, Patrick G.; Buckley, Naomi M.; Eccles, Kevin S.; Lawrence, Simon E.; Maguire, Anita R.; Collins, Stuart G.
The Journal of Organic Chemistry
Synthesis of cyclic alpha-diazo-beta-keto sulfoxides in batch and continuous flow
In Press
WOS: 11 ()
Optional Fields
α-diazo-β-keto-sulfoxide Diazo transfer Continuous flow Amberlyst A21
Diazo transfer to beta–keto sulfoxides to form stable isolable alpha-diazo-beta-keto sulfoxides has been achieved for the first time. Both monocyclic and benzofused ketone derived beta-keto sulfoxides were successfully explored as substrates for diazo transfer. Use of continuous flow leads to isolation of the desired compounds in enhanced yields relative to standard batch conditions, with short reaction times, increased safety profile and potential to scale up.
Grant Details
Irish Research Council