Peer-Reviewed Journal Details
Mandatory Fields
Shanahan, Rachel; Reen, F. Jerry; Cano, Rafael; O'Gara, Fergal; McGlacken, Gerard P.
2017
January
Organic & Biomolecular Chemistry
The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
Published
WOS: 11 ()
Optional Fields
Cell signalling Anti-cacterial agents Dose-response relationship, drug Microbial sensitivity tests Molecular structure Pseudomonas aeruginosa Quinolones Quorum sensing Signal transduction Structure-activity relationship Antibiotics Bacteria
15
306
310
The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.
CAMBRIDGE
1477-0520
https://pubs.rsc.org/en/content/articlelanding/2017/ob/c6ob01930g
10.1039/c6ob01930g
Grant Details