Peer-Reviewed Journal Details
Mandatory Fields
Ryan, Paul M.; London, Lis E. E.; Bjorndahl, Trent C.; Mandal, Rupasri; Murphy, Kiera; Fitzgerald, Gerald F.; Shanahan, Fergus; Ross, R. Paul; Wishart, David S.; Caplice, Noel M.; Stanton, Catherine
2017
March
Microbiome
Microbiome and metabolome modifying effects of several cardiovascular disease interventions in apo-E-/- mice
Validated
WOS: 50 ()
Optional Fields
Apo-E-deficient Atherosclerosis Cardiovascular disease Microbiome Metabolome
5
30
1
13
There is strong evidence indicating that gut microbiota have the potential to modify, or be modified by the drugs and nutritional interventions that we rely upon. This study aims to characterize the compositional and functional effects of several nutritional, neutraceutical, and pharmaceutical cardiovascular disease interventions on the gut microbiome, through metagenomic and metabolomic approaches. Apolipoprotein-E-deficient mice were fed for 24weeks either high-fat/cholesterol diet alone (control, HFC) or high-fat/cholesterol in conjunction with one of three dietary interventions, as follows: plant sterol ester (PSE), oat -glucan (OBG) and bile salt hydrolase-active Lactobacillus reuteri APC 2587 (BSH), or the drug atorvastatin (STAT). The gut microbiome composition was then investigated, in addition to the host fecal and serum metabolome.
2049-2618
http://dx.doi.org/10.1186/s40168-017-0246-x
10.1186/s40168-017-0246-x
Grant Details