Burke, Daniel G.; Fouhy, Fiona; Harrison, M. J.; Rea, Mary C.; Cotter, Paul D.; O’Sullivan, Orla; Stanton, Catherine; Hill, Colin; Shanahan, Fergus; Plant, Barry J.; Ross, R. Paul

2017

March

BMC Microbiology

The altered gut microbiota in adults with cystic fibrosis

Published

WOS: 73 ()

Cystic fibrosis Gut microbiota 454-pyrosequencing Microbial diversity Antibiotic therapy

17

1

58

Cystic Fibrosis (CF) is an autosomal recessive disease that affects the function of a number of organs, principally the lungs, but also the gastrointestinal tract. The manifestations of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction in the gastrointestinal tract, as well as frequent antibiotic exposure, undoubtedly disrupts the gut microbiota. To analyse the effects of CF and its management on the microbiome, we compared the gut microbiota of 43 individuals with CF during a period of stability, to that of 69 non-CF controls using 454-pyrosequencing of the 16S rRNA gene. The impact of clinical parameters, including antibiotic therapy, on the results was also assessed.

1471-2180

10.1186/s12866-017-0968-8

Science Foundation Ireland