Peer-Reviewed Journal Details
Mandatory Fields
Crean, A.,O'Mahony, C.,Moore, A.C.
2010
European Pharmaceutical Review
Development of stabilized vaccines with needle-free devices for targeted skin immunization
Validated
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Optional Fields
15
6
56
60
Vaccination represents the primary public health measure to combat infectious diseases. However, limitations of cold-chain storage, vaccine wastage, hazardous sharps-waste and the requirements for trained personnel add significant and unsustainable financial and logistic costs to immunisation programmes. Developments of needle-free methods should aim to overcome these logistics issues from the very start of the vaccine production process. Dermal vaccine administration using microneedle-based devices promises to be one such needle-free method that addresses all of these issues. Methods of stabilisation of vaccines onto or incorporated into microneedles should be developed to permit seamless transition and cost-effectiveness from vaccine bulk-up to final product. This review examines recent developments in microneedle technology and highlights the current challenges to translate this technology into practice.
http://cora.ucc.ie/handle/10468/306
Grant Details