Peer-Reviewed Journal Details
Mandatory Fields
Draper, S. J.,Moore, A. C.,Goodman, A. L.,Long, C. A.,Holder, A. A.,Gilbert, S. C.,Hill, F.,Hill, A. V.
Nature Medicine
Effective induction of high-titer antibodies by viral vector vaccines
Optional Fields
Adenoviridae/chemistry Animals Genetic Vectors/*chemistry Immunoglobulin G/chemistry Malaria/prevention & control Malaria Vaccines/*chemistry Mice Mice, Inbred BALB C Plasmodium falciparum/metabolism Plasmodium yoelii/metabolism Poxviridae/chemistry T-Lymphocytes/parasitology/*virology Vaccines/chemistry Vaccines, Subunit/chemistry Viral Vaccines/*chemistry
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
1546-170X (Electronic) 10
nm.1850 [pii] 10.1038/nm.1850
Grant Details