Peer-Reviewed Journal Details
Mandatory Fields
Draper, Simon J.,Moore, Anne C.,Goodman, Anna L.,Long, Carole A.,Holder, Anthony A.,Gilbert, Sarah C.,Hill, Fergal,Hill, Adrian V. S.
2008
August
Nature Medicine
Effective induction of high-titer antibodies by viral vector vaccines
Validated
Optional Fields
14
8
819
821
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
1078-8956
://WOS:000258237500027
10.1038/nm.1850
Grant Details