Peer-Reviewed Journal Details
Mandatory Fields
Walther, M.,Thompson, F. M.,Dunachie, S.,Keating, S.,Todryk, S.,Berthoud, T.,Andrews, L.,Andersen, R. F.,Moore, A.,Gilbert, S. C.,Poulton, I.,Dubovsky, F.,Tierney, E.,Correa, S.,Huntcooke, A.,Butcher, G.,Williams, J.,Sinden, R. E.,Hill, A. V. S.
2006
May
Infection and Immunity
Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein
Validated
()
Optional Fields
74
5
2706
2716
Heterologous prime-boost immunization with DNA and various recombinant poxviruses encoding malaria antigens is capable of inducing strong cell-mediated immune responses and partial protection in human sporozoite challenges. Here we report a series of trials assessing recombinant fowlpox virus and modified vaccinia virus Ankara encoding the Plasmodium falciparum circumsporozoite protein in various prime-boost combinations, doses, and application routes. For the first time, these vaccines were administered intramuscularly and at doses of up to 5 x 10(8) PFU. Vaccines containing this antigen proved safe and induced modest immune responses but showed no evidence of efficacy in a sporozoite challenge.
0019-9567
://WOS:000237311200023
10.1128/iai.74.5.2706-2716.2006
Grant Details