Peer-Reviewed Journal Details
Mandatory Fields
Hirenkumar Gandhi and Timothy P. O'Sullivan
2017
Unknown
Tetrahedron Letters
Preparation of γ,δ-unsaturated-β-ketoesters: Lewis acid-catalysed CH insertion of ethyl diazoacetate into α,β-unsaturated aldehydes
Published
WOS: 1 ()
Optional Fields
58
36
3533
3535
The synthesis of γ,δ-unsaturated-β-keto esters was achieved by the Lewis acid-catalysed direct CH insertion of an α-diazoester into various α,β-substituted-unsaturated aldehydes. CH insertion of ethyl diazoacetate into alkyl- and aryl-substituted α,β-unsaturated aldehydes was performed under mild conditions to afford the corresponding γ,δ-unsaturated-β-keto esters in moderate to high yields as a mixture of keto/enol tautomers.
10.1016/j.tetlet.2017.07.095
Grant Details
Irish Research Council