O'Mahony, Rosella M.; Lynch, Denis; Hayes, Hannah L. D.; Ní Thuama, Eilís; Donnellan, Philip; Jones, Roderick C.; Glennon, Brian; Collins, Stuart G.; Maguire, Anita R.

2017

December

European Journal of Organic Chemistry

Exploiting the Continuous in situ Generation of Mesyl Azide for Use in a Telescoped Process

Published

Altmetric: 19 ()

Continuous flow Diazo compounds Flow Chemistry Synthetic methods

44

6533

6539

The hazardous diazo transfer reagent mesyl azide has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β‐keto esters and a β‐ketosulfone was successful. In‐line phase separation, by means of a continuous liquid–liquid separator enabled direct telescoping with a thermal Wolff rearrangement.

1434-193X

10.1002/ejoc.201700871

Science Foundation Ireland

15/RI/3221; 12/RC/2275