Peer-Reviewed Journal Details
Mandatory Fields
Reen, F. J.,Clarke, S. L.,Legendre, C.,McSweeney, C. M.,Eccles, K. S.,Lawrence, S. E.,O'Gara, F.,McGlacken, G. P.
2012
November
Organic & Biomolecular Chemistry
Structure-function analysis of the C-3 position in analogues of microbial behavioural modulators HHQ and PQS
Validated
Optional Fields
4-Quinolones/chemical synthesis/*chemistry/*metabolism Bacillus subtilis/*physiology Biofilms Cell Line Humans Models, Molecular Pseudomonas aeruginosa/*physiology Quinolones/chemical synthesis/*chemistry/*metabolism Quorum Sensing
10
44
8903
10
2-Heptyl-3-hydroxy-4-quinolone (PQS) and its precursor 2-heptyl-4-quinolone (HHQ) are key signalling molecules of the important nosocomial pathogen Pseudomonas aeruginosa. We have recently reported an interkingdom dimension to these molecules, influencing key virulence traits in a broad spectrum of microbial species and in the human pathogenic yeast Candida albicans. For the first time, targeted chemical derivatisation of the C-3 position was undertaken to investigate the structural and molecular properties underpinning the biological activity of these compounds in P. aeruginosa, and using Bacillus subtilis as a suitable model system for investigating modulation of interspecies behaviour.
1477-0539 (Electronic) 14
https://www.ncbi.nlm.nih.gov/pubmed/23051988
10.1039/c2ob26823j
Grant Details