Peer-Reviewed Journal Details
Mandatory Fields
Shanahan, R.,Reen, F. J.,Cano, R.,O'Gara, F.,McGlacken, G. P.
2017
January
Organic & Biomolecular Chemistry
The requirements at the C-3 position of alkylquinolones for signalling in Pseudomonas aeruginosa
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15
2
306
310
The 'perfect storm' of increasing bacterial antibiotic resistance and a decline in the discovery of new antibiotics, has made it necessary to search for new and innovative strategies to treat bacterial infections. Interruption of bacterial cell-to-cell communication signalling (Quorum Sensing), thus neutralizing virulence in pathogenic bacteria, is a growing area. 2-Alkyl-4-quinolones, HHQ and PQS, play a key role in the quorum sensing circuitry of P. aeruginosa. We report a new set of isosteres of 2-heptyl-6-nitroquinolin-4-one, with alterations at C-3, and evaluate the key structural requirements for agonistic and antagonistic activity in Pseudomonas aeruginosa.
1477-0539 (Electronic) 14
https://www.ncbi.nlm.nih.gov/pubmed/27901165
10.1039/c6ob01930g
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