Other Publication Details
Mandatory Fields
Reviews
Hegarty, SV;O'Keeffe, GW;Sullivan, AM
2014
October
Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease
Validated
1
WOS: 36 ()
Optional Fields
MIDBRAIN DOPAMINERGIC-NEURONS GROWTH-DIFFERENTIATION FACTOR-5 GROWTH/DIFFERENTIATION FACTOR 5 IN-VITRO IMPROVES SURVIVAL BETA-SUPERFAMILY CONTROLLED-TRIAL DOUBLE-BLIND FACTOR GDNF RAT MODEL
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
SHENYANG
SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES
1673-5374
1708
1711
10.4103/1673-5374.143410
Grant Details