Regarding the analysis of European economic policy choices since 2010, the literature has largely taken the path of intergovernmentalism, concluding that the member states were the key leaders of the economic and fiscal negotiations and relegating the Commission to the loser status. This article aims to open the black box of European economic policy-making through process tracing and embed a discussion on policy entrepreneurship by the Commission within an analysis of policy change in economic governance. It argues that the coupling of a high problem load with a high level of systemic ambiguity opens a window of opportunity for bottom-up entrepreneurship of the Directorate General for Economic and Financial Affairs which is snuffed out by the political College and the member states when the problem load and the systemic ambiguity are low.