Peer-Reviewed Journal Details
Mandatory Fields
Marron, L;Emerson, N;Gahan, CGM;Hill, C
1997
December
Applied and Environmental Microbiology
A mutant of Listeria monocytogenes LO28 unable to induce an acid tolerance response displays diminished virulence in a murine model
Validated
WOS: 47 ()
Optional Fields
SURVIVAL
63
4945
4947
Exposing Listeria monocytogenes LO28 to sublethal pH induces protection against normally lethal pH conditions, a phenomenon known as the acid tolerance response. We identified a mutant, L. monocytogenes ATR1, which is incapable of inducing such tolerance, either against low pH or against any other stress tested. The virulence of this mutant was considerably decreased, suggesting that the acid tolerance response contributes to in vivo survival of L. monocytogenes.
WASHINGTON
0099-2240
Grant Details