Peer-Reviewed Journal Details
Mandatory Fields
Goulding, RM;Stevenson, NJ;Murray, DM;Livingstone, V;Filan, PM;Boylan, GB
2017
April
Pediatric Research
Heart rate variability in hypoxic ischemic encephalopathy during therapeutic hypothermia
Validated
WOS: 16 ()
Optional Fields
WHOLE-BODY HYPOTHERMIA RANDOMIZED-CONTROLLED-TRIAL BRAIN-STEM INJURY NEONATAL ENCEPHALOPATHY EEG NEWBORNS OUTCOMES
81
609
615
BACKGROUND: Therapeutic hypothermia (TH) aims to ameliorate further injury in infants with moderate and severe hypoxic ischemic encephalopathy (HIE). We aim to assess the effect of TH on heart rate variability (HRV) in infants with HIE. METHODS: Multichannel video-electroencephalography (EEG) and electrocardiography were assessed at 6-72 h after birth in full-term infants with HIE, recruited prior to (pre-TH group) and following (TH group) the introduction ofTH in our neonatal unit. HIE severity was graded using EEG. HRV features investigated include: mean NN interval (mean NN), standard deviation of NN interval (SDNN), triangular interpolation (TINN), high-frequency (HF), low-frequency (LF), very low-frequency (VLF), and LF/HF ratio. Linear mixed model comparisons were used. RESULTS: 118 infants (pre-TH: n=44, TH: n=74) were assessed. The majority of HRV features decreased with increasing EEG grade. Infants with moderate HIE undergoing TH had significantly different HRV features compared with the preTH group (HF: P=0.016, LF/HF ratio: P=0.006). In the pre-TH group, LF/HF ratio was significantly different between moderate and severe HIE grades (P=0.002). In the TH group, significant differences were observed between moderate and severe HIE grades for SDNN: P=0.020, TINN: P=0.005, VLF: P=0.029, LF: P=0.010, and HF: P=0.006. CONCLUSION: The HF component of HRV is increased in infants with moderate HIE undergoing TH.
NEW YORK
0031-3998
10.1038/pr.2016.245
Grant Details