Peer-Reviewed Journal Details
Mandatory Fields
Cano, R;Perez, JM;Ramon, DJ;McGlacken, GP
2016
February
Tetrahedron
Impregnated palladium on magnetite as catalyst for direct arylation of heterocycles
Validated
WOS: 29 ()
Optional Fields
C-H FUNCTIONALIZATION NANO-POWDER MAGNETITE CROSS-COUPLING REACTIONS METAL-ORGANIC FRAMEWORK HETEROGENEOUS CATALYST BOND FUNCTIONALIZATION SELECTIVE ARYLATION RECYCLABLE CATALYST SUPPORTED CATALYSTS MILD CONDITIONS
72
1043
1050
Palladium impregnated on magnetite is an efficient, cheap and easy to prepare catalyst for the direct arylation of heterocycles. Good yields are afforded under relatively mild conditions and a broad substrate scope is evident. The catalyst is regioselective in many cases, affording arylated products, at the C2- or C3-position (depending of the heterocycle used). The methodology can be extended to prepare chromenes through an intramolecular direct arylation reaction. Some evidence is provided for two catalyst deactivation pathways, which prevents efficient recycling. (C) 2015 Published by Elsevier Ltd.
OXFORD
0040-4020
10.1016/j.tet.2015.12.039
Grant Details