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Mandatory Fields
Reviews
Long-Smith, CM;Sullivan, AM;Nolan, YM
2009
November
The influence of microglia on the pathogenesis of Parkinson's disease
Validated
1
WOS: 203 ()
Optional Fields
TUMOR-NECROSIS-FACTOR NF-KAPPA-B LIPOPOLYSACCHARIDE-INDUCED NEUROTOXICITY NONSTEROIDAL ANTIINFLAMMATORY DRUGS INDUCED DOPAMINERGIC NEUROTOXICITY BACTERIAL-ENDOTOXIN EXPOSURE CENTRAL-NERVOUS-SYSTEM NITRIC-OXIDE SYNTHASE SUBSTANTIA-NIGRA MOUSE MODEL
Parkinson's disease (PD) is characterised by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Inflammation may be associated with the neuropathology of PD due to the following accumulating evidence: excessive microglial activation and increased levels of the proinflammatory cytokines turnout necrosis factor-alpha and interleukin-1 beta in the SNpc of patients with PD; the emergence of PD-like symptoms following influenza infection; the increased susceptibility to PD associated with bacterial vaginosis; the presence of inflammatory mediators and activators in animal models of PD: the ability of anti-inflammatory drugs to decrease susceptibility to PD; and the emerging possibility of the use of microglial activation inhibitors as a therapy in PD. In this review, we will discuss the role of inflammation in PD. We will focus on the influence of microglia in the pathogenesis of PD and discuss potential therapeutic interventions for PD, that target microglia. (C) 2009 Elsevier Ltd. All rights reserved.
OXFORD
PERGAMON-ELSEVIER SCIENCE LTD
0301-0082
277
287
10.1016/j.pneurobio.2009.08.001
Grant Details