Peer-Reviewed Journal Details
Mandatory Fields
Guinane, CM;Lawton, EM;O'Connor, PM;O'Sullivan, O;Hill, C;Ross, RP;Cotter, PD
2016
August
Anaerobe
The bacteriocin bactofencin A subtly modulates gut microbial populations
Validated
WOS: 25 ()
Optional Fields
MAMMALIAN GASTROINTESTINAL-TRACT LACTOBACILLUS-SALIVARIUS UCC118 LACTOCOCCUS-LACTIS ESCHERICHIA-COLI CAMPYLOBACTER RATS
40
41
49
The diverse and dynamic microbiota of the gastrointestinal tract represents a vast source of bioactive substances. These include bacteriocins, which are antimicrobial peptides with the potential to modulate gut populations to impact positively on human health. Although several gut-derived bacteriocins have been isolated, there remain only a few exceptional studies in which their influence on microbial populations within the gut has been investigated. To facilitate such investigations, in vitro faecal fermentation systems can be used to simulate the anaerobic environment of the colon. In this instance, such a system was employed to explore the impact of bactofencin A, a novel broad spectrum class lid bacteriocin produced by gut isolates of Lactobacillus salivarius, on intestinal populations and overall microbial diversity. The study reveals that, although bactofencin A is a broad spectrum bacteriocin, it has a relatively subtle influence on intestinal communities, with a potentially positive impact on anaerobic populations such as Bacteroides, Clostridium and Bifidibacterium spp. The strategy taken is an important first step in investigating the merits of using bactofencin A to manipulate the gut microbiota in a beneficial way for health. (C) 2016 Elsevier Ltd. All rights reserved.
OXFORD
1075-9964
10.1016/j.anaerobe.2016.05.001
Grant Details