Peer-Reviewed Journal Details
Mandatory Fields
Mc Gillicuddy, A;Kelly, M;Sweeney, C;Carmichael, A;Crean, AM;Sahm, LJ
2016
August
International Journal of Pharmaceutics
Modification of oral dosage forms for the older adult: An Irish prevalence study
Validated
WOS: 8 ()
Optional Fields
DOSE DRUG-THERAPY NASOGASTRIC TUBE AGED-CARE DYSPHAGIA TABLETS PHARMACOKINETICS MEDICATION MEDICINES PEOPLE PHARMACODYNAMICS
510
386
393
Age-related pharmacological changes complicate oral dosage form (ODF) suitability for older adults. The aim of this study was to investigate the appropriateness of ODF for older adults by determining the prevalence of ODF modifications in an aged care facility in Ireland. Drug charts for eligible patients were obtained. Details of all medications administered were recorded. ODF modifications were examined to determine if they were evidence-based: defined as complying with the product license or best practice guidelines (BPG). In total, of 111 patients, 35.1% received at least one modified medicine. Medicines were most commonly modified to facilitate fractional dosing (82.0%). Of the 68 instances of medicine modification, 35.3% complied with the product license. Of the 44 unlicensed modifications, 14 complied with BPG. Therefore, 44.1% of modifications were not evidence-based. This study highlights that clinicians have to routinely tailor commercial ODF to meet older patients' needs despite the lack of an evidence-base for almost half of these modifications. The main factor contributing to these modifications is the lack of appropriate, licensed dosage forms. However, reimbursement policies also play a role. Research is needed to optimise medicine administration and to provide clinicians with much needed evidence to support their daily practice. (C) 2016 Elsevier B.V. All rights reserved.
AMSTERDAM
0378-5173
10.1016/j.ijpharm.2016.06.056
Grant Details