Peer-Reviewed Journal Details
Mandatory Fields
Sullivan, AM;Opacka-Juffry, J;Pohl, J;Blunt, SB
1999
February
Brain Research
Neuroprotective effects of growth/differentiation factor 5 depend on the site of administration
Validated
WOS: 27 ()
Optional Fields
DOPAMINERGIC-NEURONS
818
176
179
Growth/differentiation factor 5 (GDF5) is a neurotrophin which protects the rat nigrostriatal dopaminergic pathway fr om 6-hydroxy-dopamine-induced damage. Here we used amphetamine-induced rotational testing, high-performance liquid chromatography and immunocytochemistry to investigate the minimum effective dose of GDF5. Wt also compared the effectiveness of injecting GDF5 into either the substantia nigra pars compacta (SNpc), the lateral ventricle (LV) or the striatum (or combinations of these sites). (C) 1999 Elsevier Science B.V. All rights reserved.
AMSTERDAM
0006-8993
Grant Details