Peer-Reviewed Journal Details
Mandatory Fields
Ajuebor, J;McAuliffe, O;O'Mahony, J;Ross, RP;Hill, C;Coffey, A
2016
June
Science Progress
Bacteriophage endolysins and their applications
Validated
WOS: 16 ()
Optional Fields
RESISTANT STAPHYLOCOCCUS-AUREUS WALL-BINDING DOMAIN STREPTOCOCCUS-PNEUMONIAE STRAINS BROAD ANTIMICROBIAL ACTIVITY RECOMBINANT PHAGE ENDOLYSIN N-TERMINAL REGION CELL-WALL LYTIC ACTIVITY LISTERIA-MONOCYTOGENES BACTERICIDAL ACTIVITY
99
183
199
Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant. Lysins have been used successfully to eliminate/control bacterial pathogens in various anatomical locations in mouse and other animal models. Engineering tactics have also been successfully applied to improve lysin function. This review discusses the structure and function of lysins. It highlights protein-engineering tactics utilised to improve lysin activity. It also reviews the applications of lysins towards food biopreservation, therapeutics, biofilm elimination and diagnostics.
ST ALBANS
0036-8504
10.3184/003685016X14627913637705
Grant Details