Other Publication Details
Mandatory Fields
Reviews
Rennie, J;Boylan, G
2007
March
Treatment of neonatal seizures
Validated
1
WOS: 37 ()
Optional Fields
DEVELOPING RAT-BRAIN CEREBRAL-BLOOD-FLOW ANTIEPILEPTIC DRUGS RECURRENT SEIZURES STATUS EPILEPTICUS IMMATURE RATS TOPIRAMATE EPILEPSY
Newborn babies with unusual movements thought to represent seizures are usually given a loading dose of phenobarbitone without electroencephalography being performed. Antlepileptic drugs (AEDs) are then continued, with the outcome determined by clinical observation alone. AED treatment, often involving multiple drugs for long periods, is undesirable at a time when the brain is developing rapidly and likely to be especially vulnerable to any toxic effects. Despite considerable advances in the pharmacology of AEDs, continuous EEG monitoring using compact digital systems with simultaneous videorecording allowing off-line analysis, automated seizure detection, neuroimaging, and basic science research on cellular mechanisms of brain injury, treatment of such babies has progressed little. A change in practice is long overdue to allow affected babies to benefit from the advances made.
LONDON
B M J PUBLISHING GROUP
1359-2998
148
150
10.1136/adc.2004.068551
Grant Details