Boylan, GB;Rennie, JM;Chorley, G;Pressler, RM;Fox, GF;Farrer, K;Morton, M;Binnie, CD

2004

February

Journal of Neurology

Second-line anticonvulsant treatment of neonatal seizures - A video-EEG monitoring study

Validated

WOS: 103 ()

62

486

488

The authors conducted a randomized trial of second-line anticonvulsant treatments for neonates. The response to treatment was assessed using continuous video-EEG)because the clinical diagnosis of seizure in neonates is known to be unreliable. Of 27 neonates with EEG-confirmed seizures, 5 were excluded because of protocol violations, and 11 responded to phenobarbitone in a dose of 40 mg/kg as first line. Three of five neonates treated with lignocaine responded. Six neonates were treated with benzodiazepines as second line: None responded, and their neurodevelopmental outcome was poor.

PHILADELPHIA

0028-3878