Peer-Reviewed Journal Details
Mandatory Fields
Doyle, B;Caplice, N
2007
May
Journal of The American College of Cardiology
Plaque neovascularization and antiangiogenic therapy for atherosclerosis
Validated
WOS: 179 ()
Optional Fields
FIBROBLAST-GROWTH-FACTOR HUMAN CORONARY-ARTERIES VASCULAR-PERMEABILITY FACTOR ADVENTITIAL VASA VASORUM IN-VIVO PATHOPHYSIOLOGICAL SIGNIFICANCE MATRIX METALLOPROTEINASES ANGIOGENESIS INHIBITORS MYOCARDIAL-INFARCTION INTIMAL HYPERPLASIA
49
2073
2080
The concept that neovascularization of the vessel wall may play a fundamental role in the pathophysiology of atherosclerosis was proposed more than a century ago. In recent years, supportive experimental evidence for this hypothesis (such as the finding that neointimal microvessels may increase delivery of cellular and soluble lesion components to the vessel wall) has been underscored by clinical studies associating plaque angiogenesis with more rapidly progressive high-grade disease. Attention has also focused on a possible role for microvessel-derived intraplaque hemorrhage in the development of acute lesion instability. The interest of clinicians in this phenomenon has been spurred by the potential to target vessel wall neovascularization with angiogenesis inhibitors, a therapeutic approach that has been associated with impressive reductions in plaque progression in animal models of vascular disease. The rationale for pursuing an "antiangiogenic" strategy in the treatment of patients with vascular disease, and a framework for further preclinical evaluation of such therapy, is presented here.
NEW YORK
0735-1097
Grant Details